DropBot by Sci-Bots is a portable, general-purpose Digital Microfluidic control system that can be used to manipulate discrete droplets using electrostatic forces on an insulated array of electrodes; a format also commonly referred to as Electrowetting on a Dielectric (EWOD). This small and rugged instrument can be controlled via USB with easy-to-use software that supports graphical programming (i.e., users can simply click and drag drops using a real-time video overlay). Sequences of steps can be pre-programmed and run automatically, enabling fully automated operation.