microfluidic ChipShop’s Publications

Selected Journal and Book Publications

[1] Zuieva A., et al., Real-time monitoring of immediate drug response and adaptation upon repeated treatment in a microfluidic chip system, Arch Toxicol, 96(5):1483-1487, 2022.

[2] Ghafoory S., et al., Oxygen Gradient Induced in Microfluidic Chips Can Be Used as a Model for Liver Zonation, Cells, 11(23):3734, 2022.

[3] Tombelli S., et al., An integrated device for fast and sensitive immunosuppressant detection, Anal Bioanal Chem, 0216-021-03847, 2021.

[4] Hochstetter A., et al., Deterministic Lateral Displacement: Challenges and Perspectives, ACS Nano, 14(9):10784-10795, 2020.

[5] Reyes RR., et al., Accelerating innovation and commercialization through standardization of microfluidicbased medical devices, Lab Chip, 21(1):9-21, 2021.

[6] Nair AL., et al., Parallelizable Microfluidic platform to model and assess in vitro cellular barriers: technology and application to study the interaction of 3D tumor spheroids with cellular barriers, Biosensors, 11(9):314, 2021.

[7] Busche M., et al., HepaChip-MP – a twenty-four chamber microplate for a continuously perfused liver coculture model, Lab Chip, 20, 2911-2926, 2020.

[8] Sandetskaya N., et al., An integrated homogeneous SPARCL™ immunoassay for rapid biomarker detection on a chip, Anal. Methods, 19, 2542-2550, 2019.

[9] Martens D., et al., A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine, Analytical methods, 10 (25), 3066-3073, 2018.

[10] Ramirez-Priego P., et al., Label-Free and Real-Time Detection of Tuberculosis in Human Urine Samples Using a Nanophotonic Point-of-Care Platform, ACS sensors, 3 (10), 2079-2086, 2018.

[11] Sandetskaya N., et al., An integrated versatile lab-on-a-chip platform for the isolation and nucleic acid-based detection of pathogens, Future Sci. OA 3(2), FSO177, 2017.

[12] Theobald, J. et al., Monitoring cytochrome P450 activity in living hepatocytes by chromogenic substrates in response to drug treatment or during cell maturation, Arch.Toxicol., 1-17, 2017 (DOI 10.1007/s00204-017-2128-1).

[13] Smith S., et al., Microfluidic Cartridges for Automated, Point-of-Care Blood Cell Counting, SLAS TECHNOLOGY, 22(2), 176-185, 2017.

[14] Theobald, J. et al., Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites, ACS Biomater. Sci. Eng., DOI: 10.1021/acsbiomaterials.7b00417, 2017.

[15] Beer, M. et al., A novel microfluidic 3D platform for culturing pancreatic ductal adenocarcinoma cells: comparison with in vitro cultures and in vivo xenografts, Sci Rep. 7, 1325, 2017.

[16] Becker H., Gärtner C., Microfluidics-Enabled Diagnostic Systems: Markets, Challenges, and Examples, in: Taly, V., Viovy, J.L., Descroix, S. (Eds.), Microchip Diagnostics: Methods and Protocols, Springer, 3-21, 2017.

[17] Marx U., et al., Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing. Altex, 33(3), 272-321, 2016.

[18] Raasch M., et al., An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development. Biomicrofluidics, 10(4), 044102, 2016.

[19] Julich S., et al., Evaluation of a microfluidic chip system for preparation of bacterial DNA from swabs, air, and surface water samples. Biologicals, 44(6), 574-580, 2016.

[20] Smith S., Sewart R., Becker H., Roux P., Land K., Blister pouches for effective reagent storage on microfluidic chips for blood cell counting. Microfluidics Nanofluidics, 20(12), 163, 2016.

[21] Wienhold T. et al., All-polymer photonic sensing platform based on whispering-gallery mode microgoblet lasers. Lab Chip 15(18), 3800-3806, 2015.

[22] Ortiz M, Joda H, Höth J, Beni V, Katakis I, Klemm R, Lind K, O’Sullivan CK, Fragoso A. Bleed‐to‐read disposable microsystems for the genetic and serological analysis of celiac disease markers with amperometric detection. Electrophoresis, 36(16), 1920-1926, 2015.

[23] Raasch M., et al., Microfluidically supported biochip design for culture of endothelial cell layers with improved perfusion conditions. Biofabrication, 7(1), 015013, 2015.

[24] Rennert K., et al., A microfluidically perfused three dimensional human liver model. Biomaterials, 71, 119-131, 2015.

[25] Gottheil R., Baur N., Becker H., Link G., Maier D., Schneiderhan-Marra N., Stelzle M., Moving the solid phase: a platform technology for cartridge based sandwich immunoassays. Biomedical Microdevices, 16(1), 163-172, 2014.

[26] Becker H., Hansen-Hagge T., Gärtner, C., Microfluidic devices for rapid identification and characterization of pathogens, in: Schaudies, R.P. (Ed.), Biological identification: DNA amplification and sequencing, optical sensing, lab-on-chip and portable systems, Elsevier, 220-250, 2014.

[27] Köhler, S. et al., Micro free-flow electrophoresis with injection molded chips, RSC Advances 2 (2), 520-525, 2012.

Selected Conference Proceedings

[1] Gaube P., et al. An integrated multiplexed chip for digital droplet loop-mediated isothermal amplification, Proc. MicroTAS 2023.

[2] Schattschneider S., et al., Minimal instrument immunoassay system by cartridge-integrated inkjet-printed optical detection system,Proc. MicroTAS 2019, Basel, 2019.

[3] Schattschneider S., Handy-LOC: a lab-on-a-chip system with integrated ink-jet printed organic semiconductor detection elements, SPIE Microfluidics, BioMEMS, and Medical Microsystems XVII 10875, 108750M, 2019.

[4] Becker H., et al., Lab-on-a-chip analyzer for zoonotic pathogens in remotely-controlled robotic air and ground vehicles, SPIE Microfluidics, BioMEMS, and Medical Microsystems XVI 10491, 104910L, 2018.

[5] Becker H., et al., Integration of silicon photonic devices in microfluidic cartridges, SPIE Microfluidics, BioMEMS, and Medical Microsystems XVI 10491, 1049108, 2018.

[6] Becker H., et al., Microfluidic devices for stem-cell cultivation, differentiation and toxicity testing, Proc. SPIE Vol 10061, pp. 1006116-1, 2017.

[7] Baldini F., et al., Novel fluorescence-based POCT platform for therapeutic drug monitoring in transplanted patients, Proc. SPIE 10072, 100720C, 2017.

[8] Becker, H., et al., Microfluidic cartridge for LAM-based TB POC-diagnostics using silicon photonics sensor, Proc. MicroTAS 2017.

[9] Becker, H., et al., Stem-cell derived two-organ model for metabolism-induced toxicity testing, Proc. MicroTAS 2017.

[10] Smith S., et al., Blister technology for the storage of liquid reagents in microfluidic devices, Proc. SPIE, Vol. 9705, 97050F, 2016.

[11] Freyberg, S., et al., Fully integrated microfluidic device for detecting tumor associated miRNA clusters for point-of-care clinical diagnostics, Proc. MicroTAS 2016.

[12] Sewart, R., et al., Universal lab-on-a-chip system for cell counting and cell density measurements in human and veterinary diagnostic applications, Proc. MicroTAS 2016.

[13] Becker, H., et al., Modular microfluidic cartridge-based universal diagnostic system for global health applications, Proc. SPIE Vol. 9705, 970514, 2016.

[14] Gärtner, Cl. Et al., Multisense chip: continuously working air monitoring system: An integrated system for the detection of airborne biological pathogens on molecular and immunological level, Proc. SPIE Vol. 9455, 94550B, 2015.

[15] Gärtner, C. et al., Sensor enhanced microfluidic devices for cell based assays and organs on chip, Proc. SPIE Vol. 9487, 948704, 2015.

[16] Gärtner, C. et al., Lab-on-a-chip enabled HLA diagnostic: combined sample preparation and real time PCR for HLA-B57 diagnosis, Proc. SPIE Vol. 9490, 94900F, 2015.

[17] Becker, H., et al., Sample-in answer-out point-of-care cartridge for fast MTB diagnostics as part of a universal diagnostic system for global health applications, Proc. MicroTAS 2015.

[18] Kiessling, H., et al., A new organ-on-chip platform for physiological relevant in-vitro reproduction of the blood-brain barrier, Proc. MicroTAS 2015.

[19] Becker, H., et al., Microfluidic system for the identification of bacterial pathogens causing urinary tract infections, Proc. SPIE Vol. 9320, 93200S, 2015.

[20] Becker, H., et al., Integrated microfluidic system with automatic sampling for permanent molecular and antigen-based detection of CBRNE-related pathogens, Proc. SPIE Vol. 9320, 93200X, 2015.

[21] Gärtner C., Sewart R., Klemm R., Becker H., Portable capillary electrophoresis-system for on-site food analysis with lab-on-a-chip based contactless conductivity detection, Proc. SPIE 9112, 911211, 2014.

[22] Klemm, R., A microfluidic platform with integrated arrays for immunologic assays for biological pathogen detection, Proc. SPIE Vol. 9073, 907311, 2014.

[23] Gärtner, C., et al., Lab-on-a-chip PCR: real time PCR in miniaturized format for HLA diagnostics, Proc. SPIE Vol. 9107, 91070O, 2014.

[24] Berrettoni, C., et al., A newly designed optical biochip for a TDM-POCT device, Proc. SPIE Vol. 8976, 89760P, 2014.

[25] Becker, H., et al., Real-time PCR in microfluidic devices, Proc. SPIE Vol. 8976, 89760Z, 2014.

[26] Becker, H., et al., Microfluidic devices for cell culture and handling in organ-on-a-chip applications, Proc. SPIE Vol. 8976, 89760N, 2014.

Publications Referring to microfluidic ChipShop’s Devices – Selected Publications

[1] Vargas R., et al. Dialysis is a key factor modulating interactions between critical process parameters during the microfluidic preparation of lipid nanoparticles, Colloid Interface Sci Commun, 54:100709, 2023.

[2] Hoyt ALM., et al., Penetration Coefficients of Commercial Nanolimes and a Liquid Mineral Precursor for PoreImitating Test Systems—Predictability of Infiltration Behavior, Materials (Basel), 6(6):2506, 2023.

[3] Iftikhar S., et.al., Droplet-based microfluidics platform for antifungal analysis against filamentous fungi, Sci Rep., 11(1):22998, 2021.

[4] Napiorkowska M., et al., High-throughput optimization of recombinant protein production in microfluidic gel beads, Small., 17(2):e2005523, 2021.

[5] Perebikovsky A., et al., Rapid sample preparation for detection of antibiotic resistance on a microfluidic disc platform, Lab Chip., 21(3):534-545, 2021.

[6] Deinhardt-Emmer S., et al., Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model, Biofabrication., 12(2):025012, 2020.

[7] Maurer M., et al., A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies, Biomaterials, doi: 10.1016/j.biomaterials.2019.119396, 2019.

[8] Lohasz C., et a., Scalable microfluidic platform for flexible configuration of and experiments with microtissue multiorgan models, SLAS Technol., 24, 79-95, 2019.

[9] Theobald J., et al., In vitro metabolic activation of vitamin D3 by using a multi-compartment microfluidic liverkidney organ on chip platform, Sci Rep., 9, 4616, 2019.

[10] Pein H., et al, Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase, Nat Commun., 9(1), 3834, 2018.

[11] Lee, J.W., et al., Low-cost and facile fabrication of a paper-based capillary electrophoresis microdevice for pathogen detection, Biosensors Bioelectronics, 91, 388-392, 2017.

[12] Petit, A.E., et al., A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion. Nature Commun. 22,7, 12242, 2016.

[13] Cheheltani, R., et al., Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging, Biomaterials, 102, 87-97, 2016.

[14] Strohmeier, O, et al., Centrifugal microfluidic platforms: advanced unit operations and applications, Chem. Soc. Rev., 44(17), 6187-6229. 2015.

[15] Rinkenauer, A.C. et al., Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo, J. Controlled Release, 216, 158-168, 2015.

[16] Mitchell, K.A., Chua, B., Son, A., Development of first generation in-situ pathogen detection system (Gen1-IPDS) based on NanoGene assay for near real time E. coli O157: H7 detection, Biosensors Bioelectronics, 54, 229-236, 2014.

[17] Hitzbleck, M., Delamarche, E., Reagents in microfluidics: an ‘in’and ‘out’challenge, Chem. Soc. Rev., 42(21), 8494-8516, 2013.

[18] Millet LJ, Gillette MU. New perspectives on neuronal development via microfluidic environments. Trends Neurosci., 35(12), 752-761, 2012.

[19] Dixit, C.K., Vashist, S.K., MacCraith. B.D., O’Kennedy. R., Multisubstrate-compatible ELISA procedures for rapid and high-sensitivity immunoassays, Nature Protocols, 6(4), 439, 20, 2011.

[20] Kurita, R., Yabumoto, N,, Niwa, O., Miniaturized one-chip electrochemical sensing device integrated with a dialysis membrane and double thin-layer flow channels for measuring blood samples, Biosensors Bioelectronics, 21(8), 1649-1653, 2006.