The pillar Fluidc 261 chip features eight chambers. Each chamber is populated with pillars of different size, pitch and shape. With its eight pillar chambers, the pillar chip Fluidic 261 can be used for a variety if applications. Pillar structures can be used to maintain particles at a certain area, to allow for self-filling of devices via capillary forces, to increase surface area, to have a sieving effect, or to use these structures for surface functionalization with high surface area regions in a microfluidic device