The spheroid monitoring/sensor chip family facilitates the insertion of pre-formed spheroids or cells to form spheroidal structures on the chip through dedicated seeding channels. The spheroids are cultivated and separated in specialized goblet-structures that are arranged along a meandering, band-like main channel. This chip family design enables real-time insight into how spheroids consume, produce, and release key factors.

Each culture unit possesses monitoring chambers to track real cellular function by enabling the measurement of cell culture medium before and after the spheroidal cultures. Optically accessible culture units support brightfield and fluorescent microscopy, enabling continuous visualization of the spheroid structures.

Key benefits:

• Dual specialized spheroid culture units for side-by-side testing
• Fully compatible with brightfield and fluorescence microscopy
• Quantify spheroid-induced changes in the culture medium
• Mini Luer ports for dedicated seeding and monitoring fluidic cycles

Fluidic 1875 features two identical microfluidic units for parallel cultivation and monitoring of spheroids and spheroidal cell cultures. Rhombic chambers placed up-stream and down-stream of the culture unit are compatible with a wide range of optical assays, including WST-8,

The four Mini Luer ports in the middle of the chip are dedicated ports to be used with PreSens‘ SensorPlugs to carry out real-time monitoring of different parameters, such as O2 or CO2 in the medium.