The micro-iPS profiler chip is a multi-organ platform featuring in total four interconnected cross-flow membrane chambers, to establish complex organoid models. Coming in standardized titer plate (Fluidic 923) or double slide format (Fluidic 1356) it ensures the compatibility with common laboratory equipment. The largest chamber is used for the preparation of a liver culture, whilst the other three chamber are used to display different types of kidney cell types.The main microfluidic circuit in the upper part connects all four chambers, for continuous perfusion. A second circuit in the lower part is used for the liver chamber solely and a third in the lower part of the three kidney chambers.The renal chambers are used for automatic media exchange (usually every 24 hours). Each chamber has individual inlet and outlet ports for cell seeding.

Fluidic 1356 features additional detection chambers and ports, compatible with the PreSens sensor system, allowing for continuous monitoring of pH, carbon dioxide and oxygen in the fluidic circuits. The ready-to-use SensorPlug consists of a Mini Luer interface, an optical fiber for read-out and a specific sensor at the tip of the fiber. The SensorPlug is mounted directly onto the microfluidic channel network, ensuring that the sensor gets into contact with the fluid pathway. Thereby, changes in the concentration can be monitored in real-time. 

The chips are only recommended for low-pressure applications, in order to avoid leakage at the sensor ports. If you don’t need the sensor ports we recommend to close them with our Mini Luer plugs or Mini Luer caps (10001687) in TPE.